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What Is Nicotinamide Riboside (NR)?

April 4, 2024, 11:42 am

When it comes to anti-aging supplements, nicotinamide riboside (NR) has been gaining attention for its potential health benefits. NR is a form of vitamin B3 that is believed to boost levels of a molecule called nicotinamide adenine dinucleotide (NAD+), which plays an important role in cellular energy production and DNA repair. This article explores what nicotinamide riboside is, its potential benefits, and how it compares to another popular supplement, nicotinamide mononucleotide (NMN).

What is Nicotinamide Riboside?

Nicotinamide riboside, a form of vitamin B3, is naturally occurring in minute amounts in certain foods like milk, yeast, and beer. It can also be produced in the body from other forms of vitamin B3, such as niacin. NR is a precursor to NAD+, a coenzyme that is involved in various cellular processes, including energy metabolism, DNA repair, and gene expression. Supplementing with NR is thought to increase NAD+ levels, which decline with age, potentially supporting overall cellular health and function.

Health Benefits of Nicotinamide Riboside

One of the main reasons why nicotinamide riboside has become popular is its potential anti-aging effects. Studies suggest that NR supplementation may help increase NAD+ levels, which decline with age. Elevated NAD+ levels are thought to promote cellular health and could potentially decelerate the aging process. NR has also been studied for its potential benefits in improving mitochondrial function, which is important for energy production in cells.

Additionally, NR may help support cardiovascular health and cognitive function, though more research is needed in these areas. NR’s ability to boost NAD+ levels may also have implications for other age-related conditions, such as metabolic dysfunction and neurodegenerative diseases. Studies suggest that nicotinamide riboside (NR) could enhance insulin sensitivity, a crucial factor in sustaining healthy blood sugar levels and reducing type 2 diabetes risk. Additionally, NR has demonstrated the ability to activate sirtuins, a class of proteins that contribute to regulating cellular health and longevity. These findings suggest that NR supplementation may have wide-ranging benefits for overall health and wellness, particularly as you age.

NMN vs. NR: Understanding the Differences

When comparing NMN vs NR, both are precursors to NAD+ but undergo different metabolic processes in the body. NMN must first be converted into NR before it can be used to produce NAD+, while NR can directly convert into NAD+. Some studies suggest that NMN may be more effective at raising NAD+ levels in certain tissues, but further research is needed to confirm these findings. Additionally, NR has demonstrated better bioavailability than NMN, indicating that more of it is absorbed and available for use by the body.

How to Take Nicotinamide Riboside

Nicotinamide riboside is available as a dietary supplement in capsule or powder form. The recommended dosage varies, but typical doses range from 100 mg to 1000 mg per day. It is generally considered safe, but like any supplement, it may cause side effects in some people, such as nausea, fatigue, or headache. Before starting any new supplement regimen, it is recommended to consult with a healthcare professional. NR can be taken with or without food, and it is often recommended to take it in the morning to support energy levels throughout the day. When starting NR supplementation, it’s advisable to begin with a lower dose and gradually increase it to assess tolerance. Some people may experience gastrointestinal discomfort when first starting NR, but this usually resolves with continued use. Additionally, NR is water-soluble, so it is important to stay hydrated while taking it to support proper absorption and effectiveness.

One Response to What Is Nicotinamide Riboside (NR)?

  1. John Ives Reply

    April 7, 2024 at 5:03 pm

    Careful — https://www.nih.gov/news-events/nih-research-matters/how-excess-niacin-may-promote-cardiovascular-disease

    I’ve stopped taking Niacinamide with the publication of this finding. I’ll resume taking the supplement if/when the NIH gives a green light.

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